Since summer 2008 the main focus of my work lies in performing association studies based on the phenotype and genotype data of the SHIP cohort (Study of Health in Pomerania). The aim of this work is to find susceptibility genes for various complex diseases.
I am a co-leader of the ThyroidOmics Consortium which studies the determinants and effects of thyroid diseases and function.
A more cost-efficient approach for identification of such susceptibility genes is the use of pooled DNA samples. For managing and analysing data from these experiments I developed a database based on Caché.
Method for a semi-automated low level quality control of a large number of Infinium HumanMethylation450 BeadChips, Seventh Workshop of Genetic Epidemiology (Hannover Medical School / University Hospital Schleswig-Holstein): Shaping Big Data in Precision Medicine and Epidemiology, April 2017, Grainau, Germany
Using Mendelian randomization to assess causality between vitamin D levels and kidney function, Seventh Workshop of Genetic Epidemiology (Hannover Medical School / University Hospital Schleswig-Holstein): Shaping Big Data in Precision Medicine and Epidemiology, April 2017, Grainau, Germany
Introduction to Imaging Genetics: Imputation & Meta-analysis, 22nd Annual Meeting of the Organization of Human Brain Mapping (OHBM), June 2016, Geneva, Switzerland
Genetic Epidemiology in the SHIP Study - an Overview and Technical Challenges, May 2016, Erasmus Medical Center Rotterdam, The Netherlands
On the Tip of Omics, Grainau, Germany: A genome-wide meta-analysis of hyper- and hypothyroidism and thyroid function, Sixth Workshop of Genetic Epidemiology (HelmholtzZentrum münchen): On the Tip of Omics, April 2016, Grainau, Germany
Genome-wide association studies identify RAB38 and HS6ST1 associated with albuminuria in diabetes, Annual Meeting of The American Society of Human Genetics (ASHG), October 2015, Baltimore, USA
A GWAS meta-analysis of circulating levels of IGF-I and IGFBP-3, Dritter Workshop zur Genetischen Epidemiologie: Genetic Variants, Omics, and Individualized Prevention, April 2013, HelmholtzZentrum münchen
A GWAS of structural thyroid parameters (size and goiter), 8. Frühjahrsakademie der Gesellschaft für Genetik: Genetic epidemiology, status quo - where to go, April 2010, HelmholtzZentrum münchen
A genome-wide association study to detect susceptibility loci for aggressive periodontitis using pooled DNA samples, International Conference: Target identification and target validation in tumour research, Juni 2008, Alfried Krupp Wissenschaftskolleg Greifswald